A phage-based decolonisation strategy against pan-resistant enterobacterial strains

Tyrothricin against Sulfonamide-resistant Strains

Demonstration of the fact that strains of pneumococci may become resistant to the antibacterial action of the sulfonamide drugs has emphasized one of the potential difficulties that may arise in the chemotherapy of pneumonia. Not only has the acquisition of drug-fastness been induced by laboratory procedures (1 to 3) but individual strains of pneumococci obtained from patients have exhibited th...

Characteristics of Streptomyces griseus strains resistant to phage.

In 1947 phage for Streptomyces griseus appeared in several commercial fermentations (Reilly, Harris and Waksman, 1947; Saudek and Colingsworth, 1947; Smith, Kiuhn, and Miesel, 1947; Woodruff, Nunheimer, and Lee, 1947). There has never been an outbreak of phage at this laboratory although a number of workers have been studying the growth of S. griseu or developing new strains. Nevertheless, in 1...

Isolation and characterization of a phage active against streptomyces griseus

Meticillin-resistant Staphylococcus aureus (MRSA): screening and decolonisation.

Meticillin-resistant Staphylococcus aureus (MRSA) infections are of increasing importance to clinicians, public health agencies and governments. Prevention and control strategies must address sources in healthcare settings, the community and livestock. This document presents the conclusions of a European Consensus Conference on the role of screening and decolonisation in the control of MRSA inf...

Application of a Novel "Pan-Genome"-Based Strategy for Assigning RNAseq Transcript Reads to Staphylococcus aureus Strains.

Understanding the behaviour of opportunistic pathogens such as Staphylococcus aureus in their natural human niche holds great medical interest. With the development of sensitive molecular methods and deep-sequencing technology, it is now possible to robustly assess the global transcriptome of bacterial species in their human habitat. However, as the genomes of the colonizing strains are often n...